Tumor OPG expression is associated with prognosis of cervical cancer in Chinese patients underwent surgical treatment

Aim: Osteoprotegerin (OPG) is associated with breast cancer in women; however, its role in cervical cancer remains unknown. This study was to investigate the association between tumor OPG expression and the prognosis in cervical cancer patients. Methods: A total of 218 patients with primary cervical cancer were enrolled in this study. All patients underwent surgical treatment as primary treatment and the tumor was obtained. The OPG Immunohistochemistry in tumor samples was performed. Results: We found that tumor OPG expression is significantly associated with tumor stage, tumor grade, metastasis and invasion (all P<0.001). Kaplan-Meier survival curves showed that cervical cancer patients with high tumor OPG levels had shorter overall survival period than the patients with low OPG levels). The univariate and multivariate Cox proportional hazard regression analyses identified tumor OPG expression in cancer as prognostic factors of cervical cancer. Conclusion: The findings of our study imply that cancer OPG expression may be used as a molecular marker for prognosis of cervical cancer patients.